How does Wellbutrin SR 300 mg Work on Depression?

The trade name of the drug bupropion is Wellbutrin SR 300 mg. It is an antidepressant. It used for the treatment of chronic depressive disorder and seasonal effective disorder. It is also used by people to quit smoking. The drug for treating depression is known to work by reducing the craving for smoking and other effects of withdrawal. The drug is also known to treat bipolar disorder, attention deficit hyperactivity disorder (ADHD) and anxiety in people with depression.


The action of this medicine is quite complex and can be understood only partly. It works by blocking reuptake of serotonin only selectively. The drug is also referred to as norepinephrine-dopamine reuptake inhibitor (NDRI).

It is also known to have antagonistic action against nicotine receptors. It is to say that the drug receptors that are usually bounded by nicotine. This results in cessation of smoking. As a matter of fact, it is capable of doubling the chance of quitting smoking.

Chronic depressive disorder


Like any other medication Wellbutrin SR 300 mg has its own side effects. The most common side effects of this medicine are:

  • Dizziness
  • Restlessness and shaking
  • Trembling
  • Anxiety
  • Dry mouth
  • Sore throat
  • Shortness of breath or hyperventilation
  • Increased perspiration
  • Arrhythmia
  • Trouble in sleeping

According to Canadian Health&Care Mall, The less common side effects are:

  • Severe headache
  • Blurred vision
  • Increased urination
  • Increased tiredness
  • Buzzing or ringing in the ears
  • Rashes
  • Itching
  • Change in taste
  • Difficulty in concentrating
  • Seizures
  • Increased heart beat
  • Aggressive behavior and increase in anger
  • Auditory and visual hallucination
  • Holding false beliefs and distrusting people
  • Fainting
  • Confusion


Prior to starting the medicine, it is important that you note some of the precautions.

Skin Reactions

Skin Reactions

If you suffer from the following reactions, you should sought medical advice:

  • Sores or ulcers
  • Severe acne
  • Feve
  • Chills and blistering
  • Loosening or peeling of the skin


Canadian Health&Care Mall healthcaremall4you states that the drug has a possibility of bringing in seizure and if you have an increased risk of seizures then you should avoid it at all costs. This group of people comprises with the following:

  • Epilepsy
  • Alcohol withdrawal
  • Anorexia nervosa
  • Active brain tumors
  • Bulimia nervosa
  • Benzodiazepine withdrawal

Monoamine Oxidase Inhibitors

WellbutrinIf you are taking monoamine oxidase inhibitors then you should not take this medicine for treating depression. If you combine these two drugs then it can lead to side effects like:

  • Pain and stomach discomfort
  • Restlessness
  • Confusion
  • Increase in body temperature
  • High blood pressure
  • Increase in the possibility of convulsions

Some of the MAOs are:

  • Sertraline
  • Paroxetine
  • Diazepam
  • Clopidogrel
  • Fluoxetine
  • Orphenadrine

You should not take this drug within two weeks of stopping MAOS. Likewise, you should not start taking MAOs within just two weeks of stopping Wellbutrin SR 300 mg.


You might have a severe allergic reaction when you take this particular drug for treating depression. This reaction is known as anaphylaxis. If you notice any of the following symptoms, you should immediately get in touch with the doctor:

  • Swelling of the face, throat, or tongue
  • Chest pain
  • Itching
  • Trouble in breathing
  • A skin rash


Make sure that you avoid alcohol while taking this medicine. This is medicine can cause dizziness and thus, you should avoid doing any task that involves concentration.